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What it is
Niacinamide, a non-flushing form of vitamin B3, which the body converts into NAD+ — a coenzyme every cell uses to shuttle electrons through energy metabolism. NAD+ is the workhorse molecule mitochondria depend on to turn fuel into ATP, and niacinamide is one of its direct dietary precursors.
Why the evidence supports it
The biochemistry here is textbook and settled: niacinamide feeds directly into NAD+, and NAD+ is central to the electron-transfer reactions mitochondria use to make energy — it also supplies the NADPH the cell uses for antioxidant defense. That makes it a clean fit for the cell's Transform function, converting fuel into usable energy. It is the gentle, non-flushing form of B3, and expectations stay grounded — feeding the energy pathway matters most when you are actually running low.
What it supports
- Supports the mitochondria as they produce cellular energy
- Provides niacinamide as an NAD+ precursor
- Supports healthy energy metabolism
- A gentle, non-flushing form of vitamin B3
Which function it supports
Ties to the cell's Transform function — niacinamide feeds the NAD+ that mitochondria use to convert fuel into ATP energy.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below — follow either link to see the mechanism in full, then dig into the studies.
What it is made of — and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions — follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (2 profiled ingredients). Structure and function only — not a treatment claim.
The science on the ingredients
Meta-analysis of 14 RCTs (~9,013 subjects), summarized in Lp(a) review literatureMeta-analysis2015
Extended-release niacin lowered Lp(a) by ~22.9% on average, but effect is apo(a)-isoform dependent.
Study authors — ~2015-2016
Ingestion of beta-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled studyRandomized controlled trial2024
A 12-week randomized, placebo-controlled trial found that oral NMN raised blood NAD+ levels in older adults and was associated with maintained walking speed and improved sleep quality compared with placebo.
Morifuji M, Higashi S, Ebihara S, et al. — GeroScience
Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism sleep and nicotinamide adenine dinucleotide biosynthesis in healthy middle-aged Japanese menRandomized controlled trial2024
Eight weeks of NMN supplementation increased NAD+ in peripheral blood cells and modestly attenuated post-meal insulin spikes in men with insulin oversecretion.
et al. — Endocrine Journal
Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy SubjectsRandomized controlled trial2022
A 12-week trial found that twice-daily oral NMN nearly doubled whole blood NAD+ levels in healthy subjects without adverse changes in body weight or blood pressure.
Okabe K, Yaku K, Uchida Y, Fukamizu Y, Sato T, Sakurai T, Tobe K, Nakagawa T — Frontiers in Nutrition
Safety evaluation of beta-nicotinamide mononucleotide oral administration in healthy adult men and womenRandomized controlled trial2022
A randomized placebo-controlled trial found 1250mg/day NMN for four weeks was well tolerated with no clinically meaningful safety signals in healthy adults.
Fukamizu Y, Uchida Y, Shigekawa A, Sato T, Kosaka H, Sakurai T — Scientific Reports
A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical TrialRandomized controlled trial2022
A randomized, placebo-controlled crossover trial found that seven days of a nicotinamide and D-ribose combination significantly increased the blood NAD+ metabolome in healthy middle-aged adults, including a 27% rise in NADP+.
Xue Y, Shamp T, Nagana Gowda GA, Crabtree M, Bagchi D, Raftery D — Nutrients
Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy IndividualsRandomized controlled trial2022
A clinical study found NMN supplementation was safely metabolized and associated with a reduction in blood triglyceride levels in healthy individuals, alongside expected rises in NAD+ metabolites.
Kimura S, Ichikawa M, Sugawara S, Katagiri T, Hirasawa Y, Ishikawa T, Matsunaga W, Gotoh A — Cureus
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older menRandomized controlled trial2022
A randomized trial in healthy older men found chronic NMN supplementation elevated blood NAD+ metabolite levels and was associated with changes in measures of muscle function, with good tolerability over the study period.
Igarashi M, Nakagawa-Nagahama Y, Miura M, Kashiwabara K, Yaku K, Sawada M, Sekine R, Fukamizu Y, Sato T, Sakurai T, Sato J, Ino K, Kubota N, Nakagawa T, Kadowaki T, Yamauchi T — npj Aging
Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized double-blind studyRandomized controlled trial2021
A six-week randomized trial found NMN supplementation (300-1200mg/day) associated with dose-related improvements in aerobic capacity measures in trained runners.
Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M — Journal of the International Society of Sports Nutrition
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic womenRandomized controlled trial2021
A 10-week randomized placebo-controlled trial found NMN supplementation increased insulin-stimulated glucose disposal and muscle insulin-signaling activity in prediabetic postmenopausal women.
Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S — Science
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight AdultsRandomized controlled trial2019
An 8-week randomized, placebo-controlled trial found that nicotinamide riboside dose-dependently increased whole blood NAD+ levels by up to 142% in healthy overweight adults, with a favorable long-term safety profile.
Conze D, Brenner C, Kruger CL — Scientific Reports
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adultsRandomized controlled trial2018
Daily nicotinamide riboside supplementation for six weeks measurably raised blood NAD+ levels in healthy middle-aged and older adults without significant side effects.
Martens CR, Denman BA, Mazzo MR, et al. — Nature Communications
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled studyRandomized controlled trial2017
In an 8-week randomized, placebo-controlled trial of adults aged 60-80, a nicotinamide riboside and pterostilbene combination increased blood NAD+ levels by up to roughly 90% in a dose-dependent, sustained manner.
Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, Marcotulli E — npj Aging and Mechanisms of Disease
Oral nicotinamide reduces transepidermal water loss: a randomized controlled trialRandomized controlled trial2016
A year-long trial in older adults found that oral nicotinamide modestly reduced transepidermal water loss on the forehead compared with placebo.
Chen AC, Martin AJ, Dalziell RA, Halliday GM, Damian DL — Br J Dermatol
Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosaceaRandomized controlled trial2005
A 4-week trial found that a niacinamide-containing moisturizer improved measures of stratum corneum barrier function in people with rosacea.
Draelos ZD, Ertel K, Berge C — Cutis
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an UpdateExpert review2023
This review of human NMN clinical trials summarized consistent findings that oral NMN raises NAD+ levels with a generally favorable safety profile across the trials conducted to date.
Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J — Advances in Nutrition
Intensifying niacin-based biosynthesis of NAD+Expert review2021
This study traces the biochemical pathway converting dietary niacin into NAD+, the cellular coenzyme required for energy metabolism and DNA repair processes.
Study authors — PubMed Central (PMC)
The mechanism and mitigation of niacin-induced flushingExpert review2009
This review explains that niacin-induced skin flushing results from prostaglandin release after niacin activates a specific cell-surface receptor, not from a toxic reaction.
Kamanna VS, Kashyap ML — International Journal of Clinical Practice
NAD+ and Vitamin B3: From Metabolism to TherapiesExpert review2008
This foundational review traces how dietary niacin is converted into NAD+, the coenzyme central to hundreds of cellular redox and energy reactions.
Bogan KL, Brenner C — Annual Review of Nutrition
Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes.2026
In transgenic Drosophila, tissue-specific expression of the NADH-to-NAD+ converting enzyme LbNOX extended lifespan and rescued neuronal cell death from reductive stress, with muscle-specific expression offering stronger protection against oxidative stress.
Yadav S; Pan X; Li S; Martin PL; Hoang N; Chen K; Karhadkar A; Malhotra J; Zuckerman AL; Munan S; Klose MK; Wang L; Cracan V; Parkhitko AA — Science advances
Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis.2026
In mice with epidermal NAD+ depletion, reduced PARP activity and DNA damage triggered IL-36-driven skin inflammation and epidermal hyperplasia, which transdermal nicotinamide mononucleotide supplementation suppressed.
Seki T; Kim JD; Yahara Y; Uchida H; Yaku K; Karim M; Makino T; Shimizu T; Nakagawa T — JCI insight
NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence.2026
A PRISMA-guided review of 113 studies on NAD+-boosting compounds like nicotinamide riboside and mononucleotide found consistent biochemical target engagement in humans and varied metabolic and mitochondrial benefits across rodent models.
Gallagher C; Emmanuel OO — Ageing research reviews
The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.2026
A randomized, placebo-controlled trial in 65 healthy adults compared nicotinamide, nicotinamide riboside, and nicotinamide mononucleotide for their differential effects on circulating NAD+ levels and microbial metabolism.
Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frézal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B — Nature metabolism
Steroid-dependent metabolic rewiring reveals novel therapeutic and imaging approaches for glioblastoma.2026
In glioblastoma, dexamethasone-driven metabolism shunted nicotinamide toward N1-methylnicotinamide production via NNMT rather than NAD+ synthesis, a tumor-selective pathway exploited for a new imaging approach.
Allega MF; Deshmukh R; Hillinger T; Akhmetshina A; Oudin A; Bielik R; Soloviev D; Villar VH; Ackermann T; Bourmeau G; Chahal SK; Stevenson KH; Nixon C; Shaw R; Morrison GM; Chalmers AJ; Pollard SM; Lund-Johansen M; Bjerkvig R; Seano G; Niclou SP; Vik-Mo EO; Lewis DY; Sumpton D; Tardito S — Science advances
Balanced by design — we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above — Sense, Exchange, Transform, Build, Maintain, Adapt — needs the same broad base of optimal micronutrient levels running underneath it, all the time. NAD-Power is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal — here is what NAD-Power pairs with for each. Nothing works in isolation; these share the same systems.
For Energy & Mitochondria
For Epigenetics
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational — a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it — go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take with water, with or without food, usually once daily. Follow the label rather than assuming more is better.
Use code HOLISTICLOVE at checkout.
Where to get it
We are lining up the best way to get this one to you. In the meantime, reach out and we will point you the right way — or browse the full shop to see every product.
See the full shopThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
NAD-Power is niacinamide, a form of vitamin B3 the body uses to make NAD+ — a molecule your mitochondria rely on to turn fuel into cellular energy. It is a simple, well-tolerated B vitamin behind a lot of energy metabolism. It fits people who want to support the energy pathway itself.
Common questions
What does NAD-Power support?+
It supports the mitochondria as they produce cellular energy, provides niacinamide as an NAD+ precursor, supports healthy energy metabolism, and is a gentle, non-flushing form of vitamin B3.
How do I take it?+
Take with water, with or without food, usually once daily. Follow the label rather than assuming more is better.
What makes it different?+
The biochemistry is real and basic — niacinamide feeds into NAD+, which is central to how mitochondria make energy. It is a straightforward, gentle form of B3 rather than the flushing kind.