Desiccated Oyster

In Caco-2 cell models, an oyster peptide-ferrous iron chelate achieved a maximum iron absorption rate of 76%, significantly higher than ferrous sulfate, suggesting improved bioavailability relevant to iron deficiency anemia.

Zhang Y; Yang Q; Yang X; Cheng S; Du M — Foods (Basel, Switzerland)

Study found that processing technique and temperature govern flavor formation in dried oysters, with enzymatic degradation of specific proteins releasing free glutamic acid as the main umami compound, informing optimized processing methods.

Lin D; Chen YL; Huo WS; Wang JY; Zhang LJ; Huang JY; Sun LC — Food chemistry: X

In dexamethasone-induced osteoporotic rats, oyster peptide treatment reduced bone loss and improved bone microarchitecture, raising osteogenic markers osteocalcin and osteoprotegerin while lowering osteoclastic markers RANKL and Cathepsin K.

Yang W; Ma W; Qin X; Cao W; Lin H — Marine drugs

An oyster-derived zinc-chelating peptide (EHAPNHDNPGDL-Zn) increased cell viability, antioxidant enzyme activity, and testosterone content while reducing p53, p21, and Bax apoptotic protein levels in MEHP-exposed Leydig cells.

Lu Z; Huang Q; Qin X; Chen F; Li E; Lin H — Marine drugs

Sun-drying oysters shifted their microbial community and metabolome, increasing compounds tied to steroid hormone, arachidonic acid, and linoleic acid metabolism, with certain bacteria genera showing negative or positive correlations with specific metabolite groups during the drying process.

Liu J; Yu M; Wang X; Qi M; Wu M — Journal of microbiology and biotechnology

A carboxymethyl cellulose-chitosan nanogel encapsulating oyster peptides increased intestinal permeability 4.7 to 7.5-fold and absorption rate by 129 percent, with transport occurring mainly through macropinocytosis and endocytosis pathways.

Zhang P; Chen Z; Zhou L; Gao J; Zheng H; Lin H; Zhu G; Qin X; Cao W — Food chemistry

In dermal papilla cell models, marine-derived ingredients including oyster extract and a marine protein complex increased alkaline phosphatase activity, glycosaminoglycan production, and expression of hair-cycle-related genes relevant to hair growth.

Augustyniak A; Mc Mahon H — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Aerobic exercise combined with oyster peptide supplementation countered cyclophosphamide-induced late-onset hypogonadism in male rats, restoring testosterone, luteinizing hormone, and testicular antioxidant markers reduced by the CTX model.

Shi W; Liu Y; Jin Q; Wu M; Sun Q; Li Z; Liu W — Reproductive sciences (Thousand Oaks, Calif.)

In mice, oyster peptides eased cyclophosphamide-induced intestinal oxidative damage by activating the Nrf2-Keap1 antioxidant signaling pathway, suggesting potential use as a peptide nutrient to help prevent chemotherapy-related gut oxidative stress.

Chen H; Zheng H; Li T; Jiang Q; Liu S; Zhou X; Ding Y; Xiang X — Frontiers in nutrition

In adults with impaired glucose tolerance, a meal fortified with oyster mushroom powder lowered free fatty acid levels, raised GLP-1, and reduced hunger ratings compared to a control meal.

Dicks L; Jakobs L; Sari M; Hambitzer R; Ludwig N; Simon MC; Stehle P; Stoffel-Wagner B; Helfrich HP; Ahlborn J; Rühl M; Hartmann B; Holst JJ; Ellinger S — European journal of nutrition

In male rats undergoing heavy-load swimming training, oyster peptide supplementation prevented reductions in sperm count, testosterone, and testicular antioxidant activity linked to exercise-hypogonadal male condition, partly via StAR and P450scc gene expression.

Jin QG; Shi WT; Wang YC; Li SY; Xue C; Xu HR; Wu MT; Wei Y — Andrologia

A study found hybrid-pump dried Pacific oysters had lower lipid content, higher glycogen, less browning, and higher antioxidant activity with slower spoilage markers compared with hot-air dried oysters.

Neri TAN; Jung HC; Jang SK; Kang SJ; Choi BD — Food science and biotechnology

Fermented oyster extract increased body length, tibial length, and hepatic IGF-1 synthesis in rats without causing organ damage or hematological changes, an effect attributed partly to its GABA content.

Lee H; Hwang-Bo H; Ji SY; Kim MY; Kim SY; Woo M; Keum YS; Noh JS; Park JH; Lee BJ; Kim GY; Park EK; Chang YC; Jeon YJ; Choi YH — Integrative medicine research

In mice, lactate derived from fermented oyster extract was studied for effects on muscle cell energy metabolism and exercise endurance performance, using both cell culture and live animal testing.

Reid SNS; Park JH; Kim Y; Kwak YS; Jeon BH — International journal of environmental research and public health

In bone-forming cells exposed to oxidative stress, fermented oyster extract prevented DNA damage and apoptosis by preserving mitochondrial function and activating the Nrf2/HO-1 antioxidant pathway, suggesting relevance to osteoporosis-related bone cell loss.

Park C; Lee H; Han MH; Jeong JW; Kim SO; Jeong SJ; Lee BJ; Kim GY; Park EK; Jeon YJ; Choi YH — EXCLI journal

Fermented oyster extract upregulated IGF-1 and growth-hormone pathway genes and increased body length in zebrafish larvae, a mechanism linked to its bone-forming effects in osteoporosis models.

Molagoda IMN; Jayasingha JACC; Choi YH; Park EK; Jeon YJ; Lee BJ; Kim GY — Marine drugs

In rats with cyclophosphamide-induced reproductive impairment, oyster peptide supplementation was associated with improved blood androgen levels and reduced oxidative stress and pathological changes in testes and kidneys.

Li M; Zhou M; Wei Y; Jia F; Yan Y; Zhang R; Cai M; Gu R — Journal of food biochemistry

Pooled reductions in fasting glucose insulin HOMA-IR and HbA1c -- Umbrella evidence contains overlapping meta-analyses

Daneshvar M et al. — Diabetology & Metabolic Syndrome

Zinc restriction lowered testosterone in normal men over ~20 weeks; repletion in marginally deficient older men raised it; no benefit in zinc-replete men.

Systematic review — Journal of Trace Elements in Medicine and Biology

This systematic review pooled human studies on zinc status and thyroid hormone levels, finding a generally consistent but modest relationship between zinc adequacy and normal thyroid hormone concentrations.

Study authors — Biological Trace Element Research

Trace mineral deficiencies, including zinc and selenium, are common in older adults, particularly those in institutional care.

Vural Z, Avery A, Kalogiros DI, Coneyworth LJ, Welham SJM — Nutrients

Short-term oral zinc supplementation was associated with enhanced natural killer cell functionality and reduced circulating innate lymphoid cell counts in healthy young adults.

Amling L, Rink L, Bennstein SB — Journal of Translational Medicine

A randomized trial in children found daily zinc supplementation (7-20mg elemental zinc) increased antibody response versus baseline, more so in children with zinc deficiency.

et al. — Frontiers/BMJ Nutrition family journal

A randomized crossover trial found a proprietary glycoprotein-matrix zinc form produced higher blood zinc concentrations than USP zinc oxide over several hours post-dose.

Jager R, Purpura M, Davis J, Keratsopoulos N, Parra ME, Secrest AH, Tinsley GM, Taylor L — Nutrients