When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
A broad-spectrum digestive enzyme blend — proteases, amylase, and lipase — taken with food. These are the same categories of enzyme the pancreas releases to break protein, starch, and fat into absorbable pieces, so the blend lends a hand to the digestion already underway during a meal.
Why the evidence supports it
Supplemental digestive enzymes have a reasonable evidence base for easing the sense of heaviness and bloating after meals, and the mechanism is direct: proteases, amylase, and lipase break the meal into the smaller pieces the gut can actually take up. That ties straight to the cell's Exchange function — better-broken-down food means the nutrients cells need can be absorbed. The framing stays honest: this supports normal digestion and comfort, it is not a treatment for a diagnosed digestive condition.
What it supports
- Supports comfortable digestion after meals
- Provides protein-, starch-, and fat-digesting enzymes
- Supports normal nutrient absorption
- A sensible option for post-meal heaviness or bloating
Which function it supports
Ties to the cell's Exchange function — better-digested food means the nutrients cells need can actually be taken in.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below — follow either link to see the mechanism in full, then dig into the studies.
What it is made of — and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions — follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (1 profiled ingredients). Structure and function only — not a treatment claim.
The science on the ingredients
Effects of Mulberry Leaf and Corn Silk Extracts Against Alpha-Amylase and Alpha-Glucosidase In Vitro and on Postprandial Glucose in Prediabetic Individuals: A Randomized Crossover TrialEstablishedRandomized controlled trial2025
Mulberry leaf extract inhibited alpha-amylase and alpha-glucosidase in vitro and lowered the post-meal glucose rise in a randomized crossover trial, linking the enzyme mechanism directly to the human postprandial result in the same paper.
Sun Y et al. — Nutrients
Anti-stress effect of theanine on students during pharmacy practiceEmergingRandomized controlled trial2013
Lower subjective stress and salivary alpha-amylase in higher-anxiety students -- Setting and subgroup limit generalization
Unno K et al. — Pharmacology Biochemistry and Behavior
Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation Via Activation of Myeloid CellsClinical trial2017
Cited in Lustig's "Metabolical" (Chapter 14: What and how adults eat) to support the claim: "only two of them are the ones in gluten."
V.F. Zevallos et al — Gastroenterology 152 (5) (
Relora on stress in healthy premenopausal womenEmergingRandomized controlled trial2008
State anxiety improved -- Cortisol amylase sleep appetite and body measures did not improve (Magnolia plus Phellodendron evidence)
Kalman DS et al. — Nutrition Journal
Synthesis and release studies on amylose-based ester prodrugs of fenamic acid NSAIDs.2024
Researchers created colon-targeted amylose-based ester prodrugs of mefenamic acid, showing the conjugate remained stable in physiological media and activated only when amylose-degrading enzymes were present.
Chugh S; Sharma M; Chandrasen G; Mudila H; Prasher P — Therapeutic delivery
Analysis of Protein Digestion and Absorption Using a Ussing Chamber to Simulate the Environment in the Digestive Tract.2024
A Ussing chamber model with Caco-2 cells and digestive enzymes pepsin and pancreatin was used to compare digestion and absorption rates of proteins from infant formula, milk, and soy milk.
Zhang X; Kaneko M; Liu W; Stephen OA; Nakamura K; Yamaguchi M; Yoshida C; Oishi T; Kobayashi S; Mizoi K; Ogihara T — Journal of nutritional science and vitaminology
Evaluation of the Enzyme Inhibition, Antioxidant, and Antimicrobial Activities of Apricots, Plums, and Their Hybrid Fruits.2024
Comparing apricots, plums, and their hybrid found the hybrid fruit had higher antioxidant activity and inhibited acetylcholinesterase and alpha-glucosidase enzymes more than either parent fruit, while none of the fruits inhibited lipase or amylase.
Mihaylova D; Desseva I; Tumbarski Y; Popova A; Pandova S; Lante A — Plants (Basel, Switzerland)
Isolation and antioxidant activity of peptides from Chinese hairy tofu.2024
Pancreatin-hydrolyzed hairy tofu peptides showed the highest antioxidant activity among seven proteases tested, with four purified peptides significantly reducing malondialdehyde content in H2O2-stressed 293T cells at concentrations below 50 micrograms per mL.
Wu LP; Wu YX; Ke XT; Wang P; Zhang S; Zhu YT; Lu Y; Shu YJ; Jiang SY; Li CJ; Hu XQ — Journal of peptide science : an official publication of the European Peptide Society
Based on green synthesis, multisensory evaluations and molecular simulation approaches: Exploring the taste-enhancing characteristics and mechanisms of N-succinyl-L-leucine.2024
Using digestive enzymes protamex and pancreatin, researchers enzymatically synthesized N-succinyl-L-leucine, a compound that enhanced umami, saltiness, and kokumi taste sensations in sensory testing.
Huang P; Wang Z; Ma Y; Zhao X; Cui C — Food research international (Ottawa, Ont.)
Polymer Encapsulated Liposomes for Oral Co-Delivery of Curcumin and Hydroxytyrosol.2023
Curcumin and hydroxytyrosol were co-encapsulated in polymer-coated liposomes to improve their survival through the digestive tract, addressing their normally poor absorption and stability.
De Leo V; Maurelli AM; Giotta L; Daniello V; Di Gioia S; Conese M; Ingrosso C; Ciriaco F; Catucci L — International journal of molecular sciences
Ice Recrystallization Inhibition Activity of Soy Protein Hydrolysates.2023
Soy protein isolate hydrolysates inhibited ice recrystallization by up to 57 percent, with a 4-14 kDa peptide fraction showing the greatest activity linked to altered hydrogen bonding at the water-air interface.
Fomich M; Día VP; Premadasa UI; Doughty B; Krishnan HB; Wang T — Journal of agricultural and food chemistry
Antioxidant, anti-inflammatory, hypoglycemic, and anti-hyperglycemic activity of chickpea protein hydrolysates evaluated in BALB-c mice.2023
In BALB-c mice, chickpea albumin protein hydrolysates produced by alcalase or pepsin-pancreatin digestion showed antioxidant, anti-inflammatory, hypoglycemic, and anti-hyperglycemic activity in vivo, consistent with their in vitro antioxidant profile.
Navarro-Leyva A; López-Angulo G; Delgado-Vargas F; López-Valenzuela JÁ — Journal of food science
Investigating the cellular antioxidant and anti-inflammatory effects of the novel peptides in lingzhi mushrooms.2022
Protein hydrolysate peptides from lingzhi mushroom, produced using proteases like Alcalase and papain, showed free radical scavenging activity in ABTS, DPPH, and nitric oxide assays, with 2.5% concentration performing best.
Aursuwanna T; Noitang S; Sangtanoo P; Srimongkol P; Saisavoey T; Puthong S; Reamtong O; Karnchanatat A — Heliyon
An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness.2022
A pepsin-pancreatin-digested peptide from plant Rubisco protein increased leptin-induced signaling in hypothalamic tissue and promoted leptin-driven reductions in body weight and food intake in obese mice fed a high-fat diet.
Kaneko K; Takekuma Y; Goto T; Ohinata K — Scientific reports
Synthesis, Stability, and Bioavailability of Nicotinamide Riboside Trioleate Chloride.2021
A new hydrophobic nicotinamide riboside derivative, NRTOCl, showed much greater stability in water and oil-in-water emulsions than standard nicotinamide riboside chloride, while remaining partially digestible and able to release NR in simulated intestinal fluid.
Zarei A; Khazdooz L; Madarshahian S; Enayati M; Mosleh I; Lin T; Yan B; Ufheil G; Wooster TJ; Abbaspourrad A — Nutrients
Chemical and Cellular Antioxidant Activities of In Vitro Digesta of Tilapia Protein and Its Hydrolysates.2020
Study comparing tilapia protein and its hydrolysates found cellular antioxidant activity of digested samples correlated positively with chemical antioxidant capacity, suggesting protein hydrolysate production should be optimized based on post-digestion activity rather than pre-digestion measures.
Zhang X; Noisa P; Yongsawatdigul J — Foods (Basel, Switzerland)
Effect of short exposure to radiofrequency electromagnetic fields on saliva biomarkers: a study on the electrohypersensitive individuals.2019
Four consecutive short radiofrequency signal exposures produced no significant change in saliva alpha-amylase, cortisol, or immunoglobulin A levels in self-identified electrohypersensitive individuals.
Andrianome S; Yahia-Cherif L; Selmaoui B — International journal of radiation biology
Pancreatic enzyme replacement therapy after gastric resection: An update.2018
A review found that oral pancreatic enzyme replacement therapy is the primary treatment for exocrine pancreatic insufficiency and fat maldigestion that can occur following gastric resection surgery.
Antonini F; Crippa S; Falconi M; Macarri G; Pezzilli R — Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Bio-Inspired Polymer Membrane Surface Cleaning.2017
Researchers immobilized pancreatin, a mix of digestive enzymes, onto polyethersulfone membranes to create a pH- and temperature-activated self-cleaning surface capable of degrading fouling layers, evaluated through multiple membrane characterization techniques.
Schulze A; Breite D; Kim Y; Schmidt M; Thomas I; Went M; Fischer K; Prager A — Polymers
Is human saliva an indicator of the adverse health effects of using mobile phones?2013
Long-term mobile phone users showed increased salivary oxidative stress markers and decreased salivary flow, protein, albumin, and amylase activity compared to non-users, suggesting altered salivary gland function.
Hamzany Y; Feinmesser R; Shpitzer T; Mizrachi A; Hilly O; Hod R; Bahar G; Otradnov I; Gavish M; Nagler RM — Antioxidants & redox signaling
Hydrolysis of zeaxanthin esters by carboxyl ester lipase during digestion facilitates micellarization and uptake of the xanthophyll by Caco-2 human intestinal cells.2006
In lab digestion tests and cultured human intestinal cells, an enzyme in the gut broke down zeaxanthin esters from foods like wolfberry and peppers, and this breakdown increased the cells' uptake of zeaxanthin more than twelvefold.
Chitchumroonchokchai C; Failla ML — The Journal of nutrition
Pancreatic enzyme replacement therapy.2001
A review of pancreatic enzyme replacement therapy found that adequate lipase dosing timed with meals is needed to correct malabsorption caused by pancreatic exocrine insufficiency in chronic pancreatitis.
Layer P; Keller J; Lankisch PG — Current gastroenterology reports
Chronic pancreatitis: pathogenesis and management of pain.1998
Chronic pancreatitis pain arises from multiple factors including ductal pressure, ischemia, and neuronal inflammation, requiring multidisciplinary management rather than a single therapeutic approach.
Pitchumoni CS — Journal of clinical gastroenterology
Cross-linking of gelatin capsules and its relevance to their in vitro-in vivo performance.1994
A review describes how gelatin capsule cross-linking under heat and humidity stress can alter in vitro drug dissolution profiles, though bioavailability from stressed capsules is not always significantly changed.
Digenis GA; Gold TB; Shah VP — Journal of pharmaceutical sciences
Balanced by design — we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above — Sense, Exchange, Transform, Build, Maintain, Adapt — needs the same broad base of optimal micronutrient levels running underneath it, all the time. Digest-It-All is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal — here is what Digest-It-All pairs with for each. Nothing works in isolation; these share the same systems.
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational — a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it — go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take with the first few bites of a meal, especially larger or richer meals, with water. Follow the brand's serving size.
Use code HOLISTICLOVE at checkout.
Where to get it
We are lining up the best way to get this one to you. In the meantime, reach out and we will point you the right way — or browse the full shop to see every product.
See the full shopThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Digest-It-All is a broad-spectrum digestive enzyme blend — proteases, amylase, and lipase — taken with food to help your body break meals down. It is aimed at comfortable digestion and getting more out of what you eat. It fits people who feel heavy or bloated after meals.
Common questions
What does Digest-It-All support?+
It supports comfortable digestion after meals, provides protein-, starch-, and fat-digesting enzymes, supports normal nutrient absorption, and is a sensible option for post-meal heaviness or bloating.
How do I take it?+
Take with the first few bites of a meal, especially larger or richer meals, with water. Follow the brand's serving size.
What makes it different?+
Digestive enzymes are a reasonable, low-risk thing to try. Taken with the meal, it lends a hand to the breakdown your body already does. It supports normal digestion and comfort, not a diagnosed condition.